Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

Genes & development - 1 Jun 2003

Peng Xiao-Ding, Xu Pei-Zhang, Chen Mei-Ling, Hahn-Windgassen Annett, Skeen Jennifer, Jacobs Joel, Sundararajan Deepa, Chen William S, Crawford Susan E, Coleman Kevin G, Hay Nissim

Abstract excerpt

To elucidate the functions of the serine/threonine kinase Akt/PKB in vivo, we generated mice lacking both akt1 and akt2 genes. Akt1/Akt2 double-knockout (DKO) mice exhibit severe growth deficiency and die shortly after birth. These mice display impaired skin development because of a proliferation defect, severe skeletal muscle atrophy because of a marked decrease in individual muscle cell size, and impaired bone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipocytes
Share to Adipose Tissue

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Atrophy

Share to Dwarfism

Share to Embryonic and Fetal Development

Share to Osteogenesis

Share to Proto-Oncogene Proteins c-akt

Source

Open in PubMed Open full text

Identifiers

PMID: 12782654
DOI: 10.1101/gad.1089403
PMCID: PMC196068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.PMID 12782654Read ↗

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta.Semantic proximity Read ↗

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice.Semantic proximity Read ↗

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies.Semantic proximity Read ↗

Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice.Semantic proximity Read ↗

AKT2 deficiency causes sarcopenia and metabolic disorder of skeletal muscleSemantic proximity Read ↗

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene.Semantic proximity Read ↗

Development of a new model system to dissect isoform specific Akt signalling in adipocytes.Semantic proximity Read ↗

Akt is required for Stat5 activation and mammary differentiationSemantic proximity Read ↗

Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal developmentSemantic proximity Read ↗

Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling.Semantic proximity Read ↗

Physiological functions of protein kinase B/Akt.Semantic proximity Read ↗

Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.