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Article

Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice.

Journal of lipid research - 1 Nov 2014

Babaev Vladimir R, Hebron Katie E, Wiese Carrie B, Toth Cynthia L, Ding Lei, Zhang Youmin, May James M, Fazio Sergio, Vickers Kasey C, Linton MacRae F

Abstract excerpt

Macrophages play crucial roles in the formation of atherosclerotic lesions. Akt, a serine/threonine protein kinase B, is vital for cell proliferation, migration, and survival. Macrophages express three Akt isoforms, Akt1, Akt2, and Akt3, but the roles of Akt1 and Akt2 in atherosclerosis in vivo remain unclear. To dissect the impact of macrophage Akt1 and Akt2 on early atherosclerosis, we generated mice with...

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Identifiers

PMID: 25240046
DOI: 10.1194/jlr.M050633
PMCID: PMC4617132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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