Article

Allosteric MAPKAPK2 Inhibitors Improve Plaque Stability in Advanced Atherosclerosis

2021-01-12

Abstract excerpt

<h4>ABSTRACT</h4> Atherosclerotic vascular disease resulting from unstable plaques is the leading cause of morbidity and mortality in subjects with type 2 diabetes (T2D), and thus a major therapeutic goal is to discover T2D drugs that can also promote atherosclerotic plaque stability. Genetic or pharmacologic inhibition of mitogen-activated protein kinase-activated protein kinase-2 (MK2) in obese mice improves gl...

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Literature Corpus work: c6cf19d9-4a31-5336-abe2-d95d19e26cee
DOI: 10.1101/2021.01.12.426264

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