Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila UNC-13 is essential for synaptic transmission.

Nature neuroscience - 1 Nov 1999

Aravamudan B, Fergestad T, Davis W S, Rodesch C K, Broadie K

Abstract excerpt

The UNC-13 protein family has been suggested to be critical for synaptic vesicle dynamics based on its interactions with Syntaxin, Munc-18 and Doc 2alpha. We cloned the Drosophila homolog (Dunc-13) and characterized its function using a combination of electrophysiology and ultrastructural analyses. Dunc-13 contained a C1 lipid-binding motif and two C2 calcium-binding domains, and its expression was restricted to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Carrier Proteins
Share to Drosophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exocytosis

Share to Helminth Proteins

Share to Nerve Tissue Proteins

Share to Sequence Homology, Amino Acid

Share to Synaptic Transmission

Source

Identifiers

PMID: 10526334
DOI: 10.1038/14764

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila UNC-13 is essential for synaptic transmission.PMID 10526334Read ↗

UNC-13 interaction with syntaxin is required for synaptic transmission.Semantic proximity Read ↗

Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.Semantic proximity Read ↗

UNC-13 is required for synaptic vesicle fusion in C. elegans.Semantic proximity Read ↗

A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming.Semantic proximity Read ↗

Synaptic Drosophila UNC-13 is regulated by antagonistic G-protein pathways via a proteasome-dependent degradation mechanism.Semantic proximity Read ↗

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.Semantic proximity Read ↗

Synaptic exocytosis and nervous system development impaired in Caenorhabditis elegans unc-13 mutants.Semantic proximity Read ↗

The M domain in UNC-13 regulates the probability of neurotransmitter release.Semantic proximity Read ↗

Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction.Semantic proximity Read ↗

Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics.Semantic proximity Read ↗

Expression of multiple UNC-13 proteins in the Caenorhabditis elegans nervous system.Semantic proximity Read ↗

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.