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Article

Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.

Neuron - 5 Dec 2002

Yoshihara Motojiro, Littleton J Troy

Abstract excerpt

To characterize Ca(2+)-mediated synaptic vesicle fusion, we analyzed Drosophila synaptotagmin I mutants deficient in specific interactions mediated by its two Ca(2+) binding C2 domains. In the absence of synaptotagmin I, synchronous release is abolished and a kinetically distinct delayed asynchronous release pathway is uncovered. Synapses containing only the C2A domain of synaptotagmin partially recover...

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PMID: 12467593
DOI: 10.1016/s0896-6273(02)01065-6

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Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.PMID 12467593Read ↗

Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1.Semantic proximity Read ↗

Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release.Semantic proximity Read ↗

synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo.Semantic proximity Read ↗

A de novo missense mutation in synaptotagmin-1 associated with neurodevelopmental disorder desynchronizes neurotransmitter releaseSemantic proximity Read ↗

Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter release.Semantic proximity Read ↗

Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release.Semantic proximity Read ↗

A de novo missense mutation in synaptotagmin-1 associated with neurodevelopmental disorder desynchronizes neurotransmitter releaseSemantic proximity Read ↗

Synaptotagmin controls and modulates synaptic-vesicle fusion in a Ca(2+)-dependent manner.Semantic proximity Read ↗

Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse.Semantic proximity Read ↗

The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.Semantic proximity Read ↗

Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening.Semantic proximity Read ↗

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