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Article

Presynaptic neurons self-tune by inversely coupling neurotransmitter release with the abundance of CaV2 voltage-gated Ca2+ channels.

Proceedings of the National Academy of Sciences of the United States of America - 27 Aug 2024

Xiong Ame, Richmond Janet E, Kim Hongkyun

Abstract excerpt

The abundance of CaV2 voltage-gated calcium channels is linked to presynaptic homeostatic plasticity (PHP), a process that recalibrates synaptic strength to maintain the stability of neural circuits. However, the molecular and cellular mechanisms governing PHP and CaV2 channels are not completely understood. Here, we uncover a previously not described form of PHP in Caenorhabditis elegans, revealing an inverse...

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Identifiers

PMID: 39172783
DOI: 10.1073/pnas.2404969121
PMCID: PMC11363341

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