Article
Transgenic mice with -6A haplotype of the human angiotensinogen gene have increased blood pressure compared with -6G haplotype.
The Journal of biological chemistry - 24 Dec 2010
Jain Sudhir, Tillinger Andrej, Mopidevi Brahmaraju, Pandey Varunkumar G, Chauhan Chetankumar K, Fiering Steven N, Warming Soren, Kumar Ashok
Abstract excerpt
Hypertension is a serious risk factor for cardiovascular disease, and the angiotensinogen (AGT) gene locus is associated with human essential hypertension. The human AGT (hAGT) gene has an A/G polymorphism at -6, and the -6A allele is associated with increased blood pressure. However, transgenic mice containing 1.2 kb of the promoter with -6A of the hAGT gene show neither increased plasma AGT level nor increased...
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