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Article

Genome-wide identification of allelic expression in hypertensive rats.

Circulation. Cardiovascular genetics - 1 Apr 2009

Dmitrieva Renata I, Hinojos Cruz A, Grove Megan L, Bell Rebecca J, Boerwinkle Eric, Fornage Myriam, Doris Peter A

Abstract excerpt

BACKGROUND: Identification of genes involved in complex cardiovascular disease traits has proven challenging. Inbred animal models can facilitate genetic studies of disease traits. The spontaneously hypertensive rat (SHR) is an inbred model of hypertension that exists in several closely related but genetically distinct lines. METHODS AND RESULTS: We used renal gene-expression profiling across 3 distinct SHR lines...

Topics

Alleles
Animals
Blood Pressure
Disease Models, Animal
Female
Gene Expression Profiling
Genome-Wide Association Study
Humans
Hypertension
Kidney
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pedigree

Polymorphism, Single Nucleotide

Rats

Rats, Inbred SHR

Rats, Inbred WKY

Source

Open in PubMed Open full text

Identifiers

PMID: 20031574
DOI: 10.1161/CIRCGENETICS.108.809509
PMCID: PMC2760851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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