Article
Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers.
Clinical chemistry - 1 Dec 2002
Bengra Chikh, Mifflin Theodore E, Khripin Yuri, Manunta Paolo, Williams Scott M, Jose Pedro A, Felder Robin A
Abstract excerpt
BACKGROUND: Human hypertension is a complex, multifactorial disease with a heritability of more than 30-50%. A genetic screening test based on analysis of multiple single-nucleotide polymorphisms (SNPs) to assess the likelihood of developing hypertension would be helpful for disease management. METHODS: Tailed allele-specific primers were designed to amplify by PCR six biallelic SNP loci [three in G...
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