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Article

STING regulates the transformation of the proinflammatory macrophage phenotype by HIF1A into autoimmune myocarditis.

International immunopharmacology - 1 Aug 2023

Hua Xiumeng, Bao Mengni, Mo Han, Sun Zhe, Xu Mengda, Chen Xiao, Mo Xiuxue, Hu Gang, Tao Menghao, Song Jiangping

Abstract excerpt

Macrophages play an essential role in the pathogenesis of autoimmune myocarditis, but the molecular mechanism remains largely unknown. Here, the role of Stimulator of interferon gene (Sting) in autoimmune myocarditis was investigated. Six-week-old male BALB/c mice received two subcutaneous injections of 250 μg α-MyHC peptide to establish experimental autoimmune myocarditis (EAM). With single-cell RNA sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37354779
DOI: 10.1016/j.intimp.2023.110523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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