Myocardial Milieu Favors Local Differentiation of Regulatory T Cells

Abstract excerpt

Background: In the past years, several studies investigated how distinct immune cell subsets affects post–myocardial infarction repair. However, whether and how the tissue environment controls these local immune responses has remained poorly understood. We sought to investigate how antigen-specific T-helper cells differentiate under myocardial milieu’s influence. Methods: We used a transgenic T cell receptor...

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