Article
Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells.
Cell reports - 21 Mar 2017
Van der Borght Katrien, Scott Charlotte L, Nindl Veronika, Bouché Ann, Martens Liesbet, Sichien Dorine, Van Moorleghem Justine, Vanheerswynghels Manon, De Prijck Sofie, Saeys Yvan, Ludewig Burkhard, Gillebert Thierry, Guilliams Martin, Carmeliet Peter, Lambrecht Bart N
Abstract excerpt
Peripheral tolerance is crucial for avoiding activation of self-reactive T cells to tissue-restricted antigens. Sterile tissue injury can break peripheral tolerance, but it is unclear how autoreactive T cells get activated in response to self. An example of a sterile injury is myocardial infarction (MI). We hypothesized that tissue necrosis is an activator of dendritic cells (DCs), which control tolerance to...
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