Article
Experimental autoimmune myocarditis in A/J mice is an interleukin-4-dependent disease with a Th2 phenotype.
The American journal of pathology - 1 Jul 2001
Afanasyeva M, Wang Y, Kaya Z, Park S, Zilliox M J, Schofield B H, Hill S L, Rose N R
Abstract excerpt
Myocarditis in humans is often associated with an autoimmune process in which cardiac myosin (CM) is a major autoantigen. Experimental autoimmune myocarditis (EAM) is induced in mice by immunization with CM. We found that EAM in A/J mice exhibits a Th2-like phenotype demonstrated by the histological picture of the heart lesions (eosinophils and giant cells) and by the humoral response (association of IgG1...
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