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Article

Common and rare variants of WNT16, DKK1 and SOST and their relationship with bone mineral density.

Scientific reports - 19 Jul 2018

Martínez-Gil Núria, Roca-Ayats Neus, Monistrol-Mula Anna, García-Giralt Natàlia, Díez-Pérez Adolfo, Nogués Xavier, Mellibovsky Leonardo, Grinberg Daniel, Balcells Susana

Abstract excerpt

Numerous GWAS and candidate gene studies have highlighted the role of the Wnt pathway in bone biology. Our objective has been to study in detail the allelic architecture of three Wnt pathway genes: WNT16, DKK1 and SOST, in the context of osteoporosis. We have resequenced the coding and some regulatory regions of these three genes in two groups with extreme bone mineral density (BMD) (n = ∼50, each) from the...

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Identifiers

PMID: 30026596
DOI: 10.1038/s41598-018-29242-8
PMCID: PMC6053384

Genes

SOST
WNT16
DKK1
MAF

Provenance

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