Article
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.
PLoS genetics - 1 Jul 2012
Zheng Hou-Feng, Tobias Jon H, Duncan Emma, Evans David M, Eriksson Joel, Paternoster Lavinia, Yerges-Armstrong Laura M, Lehtimäki Terho, Bergström Ulrica, Kähönen Mika, Leo Paul J, Raitakari Olli, Laaksonen Marika, Nicholson Geoffrey C, Viikari Jorma, Ladouceur Martin, Lyytikäinen Leo-Pekka, Medina-Gomez Carolina, Rivadeneira Fernando, Prince Richard L, Sievanen Harri, Leslie William D, Mellström Dan, Eisman John A, Movérare-Skrtic Sofia, Goltzman David, Hanley David A, Jones Graeme, St Pourcain Beate, Xiao Yongjun, Timpson Nicholas J, Smith George Davey, Reid Ian R, Ring Susan M, Sambrook Philip N, Karlsson Magnus, Dennison Elaine M, Kemp John P, Danoy Patrick, Sayers Adrian, Wilson Scott G, Nethander Maria, McCloskey Eugene, Vandenput Liesbeth, Eastell Richard, Liu Jeff, Spector Tim, Mitchell Braxton D, Streeten Elizabeth A, Brommage Robert, Pettersson-Kymmer Ulrika, Brown Matthew A, Ohlsson Claes, Richards J Brent, Lorentzon Mattias
Abstract excerpt
We aimed to identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide association study (GWAS) meta-analyses for CBT in 3 cohorts comprising 5,878 European subjects and for BMD in 5 cohorts comprising 5,672 individuals. We then assessed selected single-nucleotide polymorphisms (SNPs) for osteoporotic fracture in 2,023 cases and...
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