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Article

Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model.

Blood - 22 Mar 2012

Greenblatt Sarah, Li Li, Slape Christopher, Nguyen Bao, Novak Rachel, Duffield Amy, Huso David, Desiderio Stephen, Borowitz Michael J, Aplan Peter, Small Donald

Abstract excerpt

Constitutive activation of FLT3 by internal tandem duplication (ITD) is one of the most common molecular alterations in acute myeloid leukemia (AML). FLT3/ITD mutations have also been observed in myelodysplastic syndrome patients both before and during progression to AML. Previous work has shown that insertion of an FLT3/ITD mutation into the murine Flt3 gene induces a myeloproliferative neoplasm, but not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22323452
DOI: 10.1182/blood-2011-10-382283
PMCID: PMC3327463

Genes

FLT3
HOXD13
NUP98

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model.PMID 22323452Read ↗

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