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Article

High rate of FGFR1 amplifications in brain metastases of squamous and non-squamous lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Jan 2014

Preusser Matthias, Berghoff Anna S, Berger Walter, Ilhan-Mutlu Aysegül, Dinhof Carina, Widhalm Georg, Dieckmann Karin, Wöhrer Adelheid, Hackl Monika, von Deimling Andreas, Streubel Berthold, Birner Peter

Abstract excerpt

OBJECTIVES: FGFR1 amplifications are common in squamous cell carcinoma and rare in adenocarcinoma of the lung, but have not been investigated in brain metastases of non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: We performed fluorescent in situ hybridization (FISH) for FGFR1 and immunohistochemistry for pAKT, PI3K, HIF1a and Ki67 in 175 NSCLC brain metastases and 11 matched primary tumors. ALK gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24183471
DOI: 10.1016/j.lungcan.2013.10.004

Genes

FGFR1
ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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