Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FGFR as potential target in the treatment of squamous non small cell lung cancer.

Cancer treatment reviews - 1 Jun 2015

Tiseo Marcello, Gelsomino Francesco, Alfieri Roberta, Cavazzoni Andrea, Bozzetti Cecilia, De Giorgi Anna Maria, Petronini Pier Giorgio, Ardizzoni Andrea

Abstract excerpt

To date therapeutic options for squamous cell lung cancer patients remain scarce because no druggable targets have been identified so far. Aberrant signaling by FGFs (fibroblast growth factors) and FGFRs (fibroblast growth factors receptors) has been implicated in several human cancers and, particularly, in squamous non-small cell lung cancer (NSCLC). FGFR gene amplifications, somatic missense mutations,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Non-Small-Cell Lung
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to Gene Amplification

Share to Gene Fusion

Share to Lung Neoplasms

Share to Protein Kinase Inhibitors

Share to Signal Transduction

Source

Identifiers

PMID: 25959741
DOI: 10.1016/j.ctrv.2015.04.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FGFR as potential target in the treatment of squamous non small cell lung cancer.PMID 25959741Read ↗

Role of FGF Receptors as an Emerging Therapeutic Target in Lung Squamous Cell CarcinomaSemantic proximity Read ↗

[Progress on the Study of Targeting FGFR in Squamous Non-small Cell Lung Cancer].Semantic proximity Read ↗

Targeting the Fibroblast Growth Factor Receptor (FGFR) Family in Lung Cancer.Semantic proximity Read ↗

FGFR-driven lung cancer: Dissecting resistance and exploring therapeutic avenues.Semantic proximity Read ↗

FGFR a promising druggable target in cancer: Molecular biology and new drugs.Semantic proximity Read ↗

Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma.Semantic proximity Read ↗

Fibroblast Growth Factor Receptor 1-4 Genetic Aberrations as Clinically Relevant Biomarkers in Squamous Cell Lung CancerSemantic proximity Read ↗

Clinical advances and challenges in targeting FGF/FGFR signaling in lung cancerSemantic proximity Read ↗

Detection of Known and Novel FGFR Fusions in Non–Small Cell Lung Cancer by Comprehensive Genomic ProfilingSemantic proximity Read ↗

Fibroblast Growth Factor Receptors: From the Oncogenic Pathway to Targeted Therapy.Semantic proximity Read ↗

Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition.Semantic proximity Read ↗

Future applications of FGF/FGFR inhibitors in cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.