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Lung cancer presenting with central nervous system metastasis: Clinicopathological and molecular analysis of 171 cases.

Annals of diagnostic pathology - 1 Apr 2023

Demleitner Madeleine, Erlenbach-Wünsch Katharina, Coras Roland, Erber Ramona, Polifka Iris, Eyüpoğlu Ilker, Fuchs Florian, Hartmann Arndt, Agaimy Abbas

Abstract excerpt

A subset of lung carcinoma presents initially with brain metastasis. Precise subtyping is mandatory for optimized treatment of these advanced aggressive carcinomas. We herein analyzed surgical biopsies from 171 Patients (99 males and 72 females aged 48-96; mean, 72), who presented with brain metastasis of lung cancer. In addition to conventional subtyping, we applied an extended immunohistochemistry (IHC) panel...

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PMID: 36634550
DOI: 10.1016/j.anndiagpath.2022.152082

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