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Article

Frequent EGFR mutations in brain metastases of lung adenocarcinoma.

International journal of cancer - 15 Sept 2006

Matsumoto Shingo, Takahashi Kenji, Iwakawa Reika, Matsuno Yoshihiro, Nakanishi Yukihiro, Kohno Takashi, Shimizu Eiji, Yokota Jun

Abstract excerpt

Lung adenocarcinomas often metastasize to the brain, and the prognosis of patients with brain metastases is still very poor. The epidermal growth factor receptor (EGFR) gene is mutated in a considerable fraction of primary lung adenocarcinomas, in particular those with drastic response to EGFR tyrosine kinase inhibitors. The present study was designed to elucidate the prevalence of EGFR mutations in brain...

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Identifiers

PMID: 16642476
DOI: 10.1002/ijc.21940

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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