Article
Next-Generation Sequencing of Stage IV Squamous Cell Lung Cancers Reveals an Association of PI3K Aberrations and Evidence of Clonal Heterogeneity in Patients with Brain Metastases.
Cancer discovery - 1 Jun 2015
Paik Paul K, Shen Ronglai, Won Helen, Rekhtman Natasha, Wang Lu, Sima Camelia S, Arora Arshi, Seshan Venkatraman, Ladanyi Marc, Berger Michael F, Kris Mark G
Abstract excerpt
UNLABELLED: Large-scale genomic characterization of squamous cell lung cancers (SQCLC) has revealed several putative oncogenic drivers. There are, however, little data to suggest that these alterations have clinical relevance. We performed comprehensive genomic profiling (including next-generation sequencing) of 79 stage IV SQCLCs and analyzed differences in the clinical characteristics of two major SQCLC...
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