Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer.

doi:10.1038/modpathol.2012.102

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Article

Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2012

Schildhaus Hans-Ulrich, Heukamp Lukas C, Merkelbach-Bruse Sabine, Riesner Katharina, Schmitz Katja, Binot Elke, Paggen Ellen, Albus Kerstin, Schulte Wolfgang, Ko Yon-Dschun, Schlesinger Andreas, Ansén Sascha, Engel-Riedel Walburga, Brockmann Michael, Serke Monika, Gerigk Ulrich, Huss Sebastian, Göke Friederike, Perner Sven, Hekmat Khosro, Frank Konrad F, Reiser Marcel, Schnell Roland, Bos Marc, Mattonet Christian, Sos Martin, Stoelben Erich, Wolf Jürgen, Zander Thomas, Buettner Reinhard

Abstract excerpt

We recently reported fibroblast growth factor receptor-type 1 (FGFR1) amplification to be associated with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. This makes FGFR1 a novel target for directed therapy in these tumors. To reproducibly identify patients for clinical studies, we developed a standardized reading and evaluation strategy for FGFR1 fluorescence in-situ hybridization (FISH)...

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PMID: 22684217
DOI: 10.1038/modpathol.2012.102
PMCID: PMC4089812

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FGFR1

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