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Article

Phosphatidylinositol 3-kinase (PI3KCA) oncogene mutation analysis and gene expression profiling in primary breast cancer patients.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013

Kandula Mahesh, Chennaboina Kalyan Kumar, Ys Ammi Raju, Raju Suryanarayana

Abstract excerpt

BACKGROUND: The phosphatidylinositol 3-kinase (PI3K) pathway plays a significant role in apoptosis, cellular proliferation and motility. The aim of the present study was to analyze mutations and gene expression profiles of the PI3KCA gene to determine any role in breast carcinomas. MATERIALS AND METHODS: We analyzed 38 breast cancers for mutations in the two PIK3CA hotspots in exons 9 and 20 by direct sequencing...

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Identifiers

PMID: 24175777
DOI: 10.7314/apjcp.2013.14.9.5067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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