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Article

PIK3CA exon 20 mutations are associated with poor prognosis in breast cancer patients.

Clinics (Sao Paulo, Brazil) - 1 Nov 2012

Mangone Flavia R, Bobrovnitchaia Irina G, Salaorni Sibeli, Manuli Erika, Nagai Maria A

Abstract excerpt

OBJECTIVES: The phosphatidylinositol 3-kinase/AKT axis is an important cell-signaling pathway that mediates cell proliferation and survival, two biological processes that regulate malignant cell growth. The phosphatidylinositol 3-kinase CA gene encodes the p110α subunit of the phosphatidylinositol 3-kinase protein. There are phosphatidylinositol 3-kinase CA mutations in several types of human tumors, and they are...

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Identifiers

PMID: 23184205
DOI: 10.6061/clinics/2012(11)11
PMCID: PMC3488987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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