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Article

PI3K mutations in breast cancer: prognostic and therapeutic implications

1 May 2015

Abstract excerpt

The PI3K pathway is the most frequently enhanced oncogenic pathway in breast cancer. Among mechanisms of PI3K enhancement, PIK3CA mutations are most frequently (∼30%) observed, along with protein loss of PTEN. Since the first discovery of PIK3CA mutations in solid malignancies in 2004, numerous studies have revealed the prognostic and therapeutic implications of these mutations. Although many issues remain...

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PMID: 26028978
DOI: 10.2147/bctt.s60696

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