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Article

Analysis of PIK3CA mutations in breast cancer subtypes.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2014

Arsenic Ruza, Lehmann Annika, Budczies Jan, Koch Ines, Prinzler Judith, Kleine-Tebbe Anke, Schewe Christiane, Loibl Sibylle, Dietel Manfred, Denkert Carsten

Abstract excerpt

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA) is a central element of a signaling pathway involved in cell proliferation, survival, and growth. Certain mutations in this pathway result in enhanced PI3K signaling, which is associated with oncogenic cellular transformation and cancer. The aims of this study were to characterize different types of PIK3CA mutations in exons 9 and 20 in a...

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PMID: 24471188
DOI: 10.1097/pdm.0b013e318297afea

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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