Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic mutation and gain of copy number of PIK3CA in human breast cancer.

Breast cancer research : BCR - 1 Jan 2005

Wu Guojun, Xing Mingzhao, Mambo Elizabeth, Huang Xin, Liu Junwei, Guo Zhongmin, Chatterjee Aditi, Goldenberg David, Gollin Susanne M, Sukumar Saraswati, Trink Barry, Sidransky David

Abstract excerpt

INTRODUCTION: Phosphatidylinositol 3-kinases (PI3Ks) are a group of lipid kinases that regulate signaling pathways involved in cell proliferation, adhesion, survival, and motility. Even though PIK3CA amplification and somatic mutation have been reported previously in various kinds of human cancers, the genetic change in PIK3CA in human breast cancer has not been clearly identified. METHODS: Fifteen breast cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromones
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Inhibitors

Share to In Situ Hybridization, Fluorescence

Share to Morpholines

Share to Neoplasm Staging

Share to Phosphatidylinositol 3-Kinases

Share to Phosphoinositide-3 Kinase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 16168105
DOI: 10.1186/bcr1262
PMCID: PMC1242128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutation and gain of copy number of PIK3CA in human breast cancer.PMID 16168105Read ↗

The PIK3CA gene is mutated with high frequency in human breast cancersSemantic proximity Read ↗

Phosphatidylinositol 3-kinase (PI3KCA) oncogene mutation analysis and gene expression profiling in primary breast cancer patients.Semantic proximity Read ↗

Clinical-Pathologic Analysis of Breast Cancer With PIK3CA Mutations in Chinese Women.Semantic proximity Read ↗

PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.Semantic proximity Read ↗

Mutation distributions and clinical correlations of PIK3CA gene mutations in breast cancer.Semantic proximity Read ↗

Molecular evaluation of PIK3CA gene mutation in breast cancer: determination of frequency, distribution pattern and its association with clinicopathological findings in Indian patients.Semantic proximity Read ↗

The PIK3CA gene as a mutated target for cancer therapy.Semantic proximity Read ↗

Evaluation of PIK3CA mutations as a biomarker in Chinese breast carcinomas from Western China.Semantic proximity Read ↗

Investigation of somatic PIK3CA gene mutations in breast cancer patients.Semantic proximity Read ↗

The High Frequency of PIK3CA Mutations in Iranian Breast Cancer Patients.Semantic proximity Read ↗

PI3K mutations in breast cancer: prognostic and therapeutic implicationsSemantic proximity Read ↗

Frequent mutation of the PIK3CA gene in ovarian and breast cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.