Article
Evaluation of PIK3CA mutations as a biomarker in Chinese breast carcinomas from Western China.
Cancer biomarkers : section A of Disease markers - 1 Jan 2017
Cheng Jingliang, Fu Shangyi, Wei Chunli, Tania Mousumi, Khan Md Asaduzzaman, Imani Saber, Zhou Baixu, Chen Hanchun, Xiao Xiuli, Wu Jingbo, Fu Junjiang
Abstract excerpt
BACKGROUND: PIK3CA gene encodes the p110 α catalytic subunit of the oncoprotein phosphatidylinositol 3-kinase (PI3 K) which regulates many biological processes such as cell proliferation, differentiation, migration and survival through the activation of various signaling pathways. OBJECTIVE: In this study, we have investigated the possible somatic mutations in PIK3CA gene in invasive ductal breast carcinomas of...
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