Article
Investigation of somatic PIK3CA gene mutations in breast cancer patients.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology - 1 Jan 2000
M.Pevzner Alina, A.Gaptulbarova Ksenia, M.Tsyganov Matvey, Κ.Ibragimova Marina, V.Vvedensky Andrew, G.Zhusina Yulia, V.Pyankov Denis, A.Korostylev Sergey, V.Litviakov Nikolai
Abstract excerpt
PURPOSE: Mutations of the PI3K/AKT/mTOR signaling pathway occur in 70% of all breast cancers and represent a clinically useful marker for disease prognosis and patient management. The purpose of this work was to study the main somatic PIK3CA gene mutations in breast cancer patients and the search for a relationship with the main clinical and pathological characteristics and the effect of neoadjuvant chemotherapy...
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