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Article

Airway reactivity and sphingolipids—implications for childhood asthma

1 Dec 2015

Abstract excerpt

Asthma is a clinically heterogeneous disorder, whose onset and progression results from a complex interplay between genetic susceptibility, allergens, and viral triggers. Sphingolipids and altered sphingolipid metabolism have emerged as potential key contributors to the pathogenesis of asthma. Orosomucoid-like 3 gene (ORMDL3) and the asthma susceptibility locus 17q21 have been strongly and reproducibly linked to...

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PMID: 26637347
DOI: 10.1186/s40348-015-0025-3

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