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Article

A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.

The Journal of allergy and clinical immunology - 1 Sept 2018

Stein Michelle M, Thompson Emma E, Schoettler Nathan, Helling Britney A, Magnaye Kevin M, Stanhope Catherine, Igartua Catherine, Morin Andréanne, Washington Charles, Nicolae Dan, Bønnelykke Klaus, Ober Carole

Abstract excerpt

Chromosome 17q12-21 remains the most highly replicated and significant asthma locus. Genotypes in the core region defined by the first genome-wide association study correlate with expression of 2 genes, ORM1-like 3 (ORMDL3) and gasdermin B (GSDMB), making these prime candidate asthma genes, although recent studies have implicated gasdermin A (GSDMA) distal to and post-GPI attachment to proteins 3 (PGAP3) proximal...

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Share to Asthma
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 17

Share to DNA Methylation

Share to GSDMB gene

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Share to Quantitative Trait Loci

Source

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Identifiers

PMID: 29307657
DOI: 10.1016/j.jaci.2017.12.974
PMCID: PMC6172038

Genes

GSDMA
ORMDL3
PGAP3
GPI
GSDMB
ORM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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