17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma.

doi:10.1164/rccm.202305-0934OC

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Article

17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma.

American journal of respiratory and critical care medicine - 15 Apr 2024

Jakwerth Constanze A, Weckmann Markus, Illi Sabina, Charles Helen, Zissler Ulrich M, Oelsner Madlen, Guerth Ferdinand, Omony Jimmy, Nemani Sai Sneha Priya, Grychtol Ruth, Dittrich Anna-Maria, Skevaki Chrysanthi, Foth Svenja, Weber Stefanie, Alejandre Alcazar Miguel A, van Koningsbruggen-Rietschel Silke, Brock Robert, Blau Samira, Hansen Gesine, Bahmer Thomas, Rabe Klaus F, Brinkmann Folke, Kopp Matthias Volkmar, Chaker Adam M, Schaub Bianca, von Mutius Erika, Schmidt-Weber Carsten B

Abstract excerpt

Rationale: The strongest genetic risk factor for childhood-onset asthma, the 17q21 locus, is associated with increased viral susceptibility and disease-promoting processes.Objectives: To identify biological targets underlying the escalated viral susceptibility associated with the clinical phenotype mediated by the 17q21 locus.Methods: Genome-wide transcriptome analysis of nasal brush samples from 261 children (78...

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PMID: 38064241
DOI: 10.1164/rccm.202305-0934OC
PMCID: PMC11531215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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