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Article

The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular Inflammation

19 Oct 2018

Abstract excerpt

RATIONALE: Polymorphisms on chromosome 17q21 confer the major genetic susceptibility to childhood-onset asthma. Risk alleles positively correlate with ORMDL3 (orosomucoid-like 3) expression. The locus influences disease severity and the frequency of human rhinovirus (HRV)-initiated exacerbations. ORMDL3 is known to regulate sphingolipid synthesis by binding serine palmitoyltransferase, but its role in...

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Identifiers

PMID: 30339462
DOI: 10.1164/rccm.201803-0438oc

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The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular InflammationPMID 30339462Read ↗

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