Article
Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors
22 Oct 2013
Abstract excerpt
Lineage tracing approaches have provided new insights into the cellular mechanisms that support tissue homeostasis in mice. However, the relevance of these discoveries to human epithelial homeostasis and its alterations in disease is unknown. By developing a novel quantitative approach for the analysis of somatic mitochondrial mutations that are accumulated over time, we demonstrate that the human upper airway...
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