Article
Clonal Somatic Mutations in Chronic Lung Diseases Are Associated with Reduced Lung Function.
American journal of respiratory and critical care medicine - 1 Dec 2023
Yun Jeong H, Khan M A Wasay, Ghosh Auyon, Hobbs Brian D, Castaldi Peter J, Hersh Craig P, Miller Peter G, Cool Carlyne D, Sciurba Frank, Barwick Lucas, Limper Andrew H, Flaherty Kevin, Criner Gerard J, Brown Kevin, Wise Robert, Martinez Fernando, Silverman Edwin K, DeMeo Dawn, Cho Michael H, Bick Alexander G
Abstract excerpt
Rationale: Constantly exposed to the external environment and mutagens such as tobacco smoke, human lungs have one of the highest somatic mutation rates among all human organs. However, the relationship of these mutations to lung disease and function is not known. Objectives: To identify the prevalence and significance of clonal somatic mutations in chronic lung diseases. Methods: We analyzed the clonal somatic...
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