Article

Recovery of human upper airway epithelium after smoking cessation is driven by a slow-cycling stem cell population and immune surveillance

2025-08-30

Abstract excerpt

<h4>SUMMARY</h4> The upper airway epithelium in humans is maintained in homeostasis by a resident population of basal stem cells. In the presence of tobacco smoke these gain mutations that significantly increase their risk of transformation to lung squamous cell carcinoma. Previous studies show that a small proportion of stem cells avoid the mutational damage caused by carcinogens in tobacco and are more abundant...

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Literature Corpus work: 00868b68-af6f-5f86-a6de-fbcc2f4e5cb0
DOI: 10.1101/2025.08.26.672394

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