Article
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking.
Nature genetics - 1 Apr 2022
Huang Zhenqiu, Sun Shixiang, Lee Moonsook, Maslov Alexander Y, Shi Miao, Waldman Spencer, Marsh Ava, Siddiqui Taha, Dong Xiao, Peter Yakov, Sadoughi Ali, Shah Chirag, Ye Kenny, Spivack Simon D, Vijg Jan
Abstract excerpt
Although lung cancer risk among smokers is dependent on smoking dose, it remains unknown if this increased risk reflects an increased rate of somatic mutation accumulation in normal lung cells. Here, we applied single-cell whole-genome sequencing of proximal bronchial basal cells from 33 participants aged between 11 and 86 years with smoking histories varying from never-smoking to 116 pack-years. We found an...
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