Article
Aberrant basal cell clonal dynamics shape early lung carcinogenesis.
Science (New York, N.Y.) - 12 Jun 2025
Gómez-López Sandra, Alhendi Ahmed S N, Przybilla Moritz J, Bordeu Ignacio, Whiteman Zoe E, Butler Timothy, Rouhani Maral J, Kalinke Lukas, Uddin Imran, Otter Kate E J, Chandrasekharan Deepak P, Lebrusant-Fernandez Marta, Shurr Abigail Y L, Durrenberger Pascal F, Moore David A, Falzon Mary, Reading James L, Martincorena Iñigo, Simons Benjamin D, Campbell Peter J, Janes Sam M
Abstract excerpt
Preinvasive squamous lung lesions are precursors of lung squamous cell carcinoma (LUSC). The cellular events underlying lesion formation are unknown. Using a carcinogen-induced model of LUSC with no added genetic hits or cell type bias, we found that carcinogen exposure leads to non-neutral competition among basal cells, aberrant clonal expansions, and basal cell mobilization along the airways. Ultimately,...
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