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Article

Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice.

Carcinogenesis - 1 Mar 2014

Abrigo Marianela, Alvarez Romina, Paparella María L, Calb Diego E, Bal de Kier Joffe Elisa, Gutkind J Silvio, Raimondi Ana R

Abstract excerpt

Oral squamous cell carcinoma (SCC) is among the most prevalent cancers in the world and is characterized by high morbidity and few therapeutic options. Like most cancers, oral SCC arises from a multistep process involving alterations of genes responsible for balancing proliferation and differentiation. Among these, Krϋppel-like factor 4 (Klf4) suppresses cell proliferation and promotes differentiation and thus...

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Source

Identifiers

PMID: 24148820
DOI: 10.1093/carcin/bgt349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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