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Article

Tissue Context Shapes Distinct Premalignant Outcomes in an HPV16 E6/E7-Mutant Pik3ca Transgenic Mouse Model.

Cancer research communications - 1 Jul 2026

Ayre Marina, Fernandez-Ugazio Gonzalo, DiGaudio Anabel V, Coso Omar Adrián, Gutkind J Silvio, Raimondi Ana Rosa

Abstract excerpt

High-risk human papillomavirus (HPV) infection, particularly HPV16, is a major etiologic factor associated with multiple human cancers, including anal, cervical, and oropharyngeal carcinomas. However, the mechanisms underlying tissue-specific responses to HPV oncogene expression remain poorly understood. In this study, we developed and characterized a double-inducible transgenic mouse model enabling spatially and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Human papillomavirus 16

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Share to Oncogene Proteins, Viral

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Source

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Identifiers

PMID: 42378452
DOI: 10.1158/2767-9764.CRC-25-0789
PMCID: PMC13389264

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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