Article

Immunomodulatory Role of Keratin 76 in Oral and Gastric Cancer

2018-04-21

Abstract excerpt

<h4>ABSTRACT</h4> Keratin 76 (Krt76) is expressed in the differentiated epithelial layers of skin, oral cavity and squamous stomach. Krt76 downregulation in human oral squamous cell carcinomas (OSCC) correlates with poor prognosis. We show that genetic ablation of Krt76 in mice leads to spleen and lymph node enlargement, an increase in regulatory T cells (Tregs) and high levels of pro-inflammatory cytokines. Krt7...

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Literature Corpus work: 28787a8b-47b4-5db8-8d1d-bccdf1b98035
DOI: 10.1101/305961

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