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Article

Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epithelium.

The American journal of pathology - 1 Jun 2011

Sistrunk Christopher, Macias Everardo, Nakayama Keiichi, Kim Yongbaek, Rodriguez-Puebla Marcelo L

Abstract excerpt

The proto-oncogene c-Myc encodes a transcription factor that is implicated in the regulation of cellular proliferation, differentiation, and apoptosis. Myc accelerates the rate of cell proliferation, at least in part, through its ability to down-regulate the expression of the cell cycle inhibitor p27(Kip1). Moreover, p27(Kip1) protein levels are regulated by ubiquitin-mediated turnover, leading to destruction by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21641375
DOI: 10.1016/j.ajpath.2011.02.034
PMCID: PMC3124025

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