Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Establishment of a p53 Null Murine Oral Carcinoma Cell Line and the Identification of Genetic Alterations Associated with This Carcinoma.

International journal of molecular sciences - 8 Dec 2020

Chang Kuo-Wei, Lin Chia-En, Tu Hsi-Feng, Chung Hsin-Yao, Chen Yi-Fen, Lin Shu-Chun

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC), including oral squamous cell carcinoma (OSCC), ranks sixth in cancer incidence worldwide. To generate OSCC cells lines from human or murine tumors, greatly facilitates investigations into OSCC. This study describes the establishing of a mouse palatal carcinoma cell line (designated MPC-1) from a spontaneous tumor present in a heterozygous p53 gene loss C57BL/6 mouse....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cadherins
Share to Cell Culture Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockout Techniques

Share to Keratinocytes

Share to Mouth Neoplasms

Share to Piperazines

Share to Pyridines

Share to Vimentin

Source

Open in PubMed Open full text

Identifiers

PMID: 33302499
DOI: 10.3390/ijms21249354
PMCID: PMC7764333

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishment of a p53 Null Murine Oral Carcinoma Cell Line and the Identification of Genetic Alterations Associated with This Carcinoma.PMID 33302499Read ↗

Mutational Landscape of Oral Squamous Cell Carcinoma Investigated Through the Developmental Dynamics of Oral Squamous EpitheliumSemantic proximity Read ↗

Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic VulnerabilitiesSemantic proximity Read ↗

Current mouse models of oral squamous cell carcinoma: Genetic and chemically induced modelsSemantic proximity Read ↗

The molecular pathogenesis of head and neck squamous cell carcinoma.Semantic proximity Read ↗

Development of a mouse model for spontaneous oral squamous cell carcinoma in Fanconi anemiaSemantic proximity Read ↗

Alterations of the p14ARF-p53-MDM2 pathway in oral squamous cell carcinoma: MDM2 overexpression is a common event.Semantic proximity Read ↗

A Surprising Cross-Species Conservation in the Genomic Landscape of Mouse and Human Oral Cancer Identifies a Transcriptional Signature Predicting Metastatic DiseaseSemantic proximity Read ↗

Molecular homology between canine spontaneous oral squamous cell carcinomas and human head-and-neck squamous cell carcinomas reveals disease drivers and therapeutic vulnerabilitiesSemantic proximity Read ↗

Transcriptomic atlas of premalignant oral squamous cell carcinoma in an aging mouse model reveals an enhanced immune response and dysregulation of head and neck tissue stem cellsSemantic proximity Read ↗

Cdkn2a suppresses metastasis in squamous cell carcinomas induced by the gain-of-function mutant p53(R172H).Semantic proximity Read ↗

TP53 gain-of-function mutation modulates the immunosuppressive microenvironment in non-HPV-associated oral squamous cell carcinoma.Semantic proximity Read ↗

Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.