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Article

Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation

16 Oct 2009

Abstract excerpt

Smad4 is a central mediator of TGF-beta signaling, and its expression is downregulated or lost at the malignant stage in several cancer types. In this study, we found that Smad4 was frequently downregulated not only in human head and neck squamous cell carcinoma (HNSCC) malignant lesions, but also in grossly normal adjacent buccal mucosa. To gain insight into the importance of this observation, we generated mice...

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PMID: 19841536
DOI: 10.1172/jci38854

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