Article
Ppp6c deficiency accelerates K-rasG12D -induced tongue carcinogenesis.
Cancer medicine - 1 Jul 2021
Kishimoto Kazuhiro, Kanazawa Kosuke, Nomura Miyuki, Tanaka Takuji, Shigemoto-Kuroda Taeko, Fukui Katsuya, Miura Koh, Kurosawa Koreyuki, Kawai Masaaki, Kato Hiroyuki, Terasaki Keiko, Sakamoto Yoshimi, Yamashita Yoji, Sato Ikuro, Tanuma Nobuhiro, Tamai Keiichi, Kitabayashi Issay, Matsuura Kazuto, Watanabe Toshio, Yasuda Jun, Tsuji Hiroyuki, Shima Hiroshi
Abstract excerpt
BACKGROUND: Effective treatments for cancer harboring mutant RAS are lacking. In Drosophila, it was reported that PP6 suppresses tumorigenicity of mutant RAS. However, the information how PP6 regulates oncogenic RAS in mammals is limited. METHODS: We examined the effects of PP6 gene (Ppp6c) deficiency on tongue tumor development in K (K-rasG12D)- and KP (K-rasG12D + Trp53-deficient)-inducible mice. RESULTS: Mice...
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