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Article

Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma.

The Journal of pathology - 1 Sept 2024

Yang Jing, Lewis James S, Zi Jinghuan, Andl Thomas, Lee Ethan, Andl Claudia D, Liu Qi, Beauchamp Robert D, Means Anna L

Abstract excerpt

SMAD4 is a tumor suppressor mutated or silenced in multiple cancers, including oral cavity squamous cell carcinoma (OSCC). Human clinical samples and cell lines, mouse models and organoid culture were used to investigate the role that SMAD4 plays in progression from benign disease to invasive OSCC. Human OSCC lost detectable SMAD4 protein within tumor epithelium in 24% of cases, and this loss correlated with...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38922866
DOI: 10.1002/path.6318
PMCID: PMC11300146

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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