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Rapamycin Prevents Early Onset of Tumorigenesis in an Oral-Specific K- <i>ras</i> and <i>p53</i> Two-Hit Carcinogenesis Model

12 May 2009

Abstract excerpt

Head and neck squamous cell carcinomas (HNSCC), the majority of which occur in the oral cavity, remain a significant cause of morbidity and mortality worldwide. A major limitation in HNSCC research has been the paucity of animal models to test the validity of current genetic paradigms of tumorigenesis and to explore the effectiveness of new treatment modalities and chemopreventive strategies. Here, we have...

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PMID: 19435901
DOI: 10.1158/0008-5472.can-08-4645

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Rapamycin Prevents Early Onset of Tumorigenesis in an Oral-Specific K- <i>ras</i> and <i>p53</i> Two-Hit Carcinogenesis ModelPMID 19435901Read ↗

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