Article

Transcriptomic atlas of premalignant oral squamous cell carcinoma in an aging mouse model reveals an enhanced immune response and dysregulation of head and neck tissue stem cells

2026-03-24

Abstract excerpt

Oral squamous cell carcinomas (OSCC) account for ∼90% of all oral malignancies and have devastating effects on overall health and quality of life. However, little is known about the early initiating events that drive the development of oral leukoplakia-like premalignant lesions (OPLs) and disease progression. Here, we create a mouse model of tobacco-related premalignant OSCC that takes into consideration its prima...

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Literature Corpus work: d3d6d85f-bc96-5292-abb2-6e1dfa7c9f34
DOI: 10.64898/2026.03.20.713236

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