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Article

The GAFa domain of phosphodiesterase-6 contains a rod outer segment localization signal.

Journal of neurochemistry - 1 Apr 2014

Cheguru Pallavi, Zhang Zhongming, Artemyev Nikolai O

Abstract excerpt

Photoreceptor phosphodiesterase-6 (PDE6) is a peripheral membrane protein synthesized in the inner segment of photoreceptor cells. Newly synthesized PDE6 is transported to the outer segment (OS) where it serves as a key effector enzyme in the phototransduction cascade. Proper localization of PDE6 in photoreceptors is critically important to the function and survival of photoreceptor cells. The mechanism of PDE6...

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Share to Cyclic Nucleotide Phosphodiesterases, Type 6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24147783
DOI: 10.1111/jnc.12501
PMCID: PMC4054601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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