Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The molecular architecture of photoreceptor phosphodiesterase 6 (PDE6) with activated G protein elucidates the mechanism of visual excitation.

The Journal of biological chemistry - 20 Dec 2019

Irwin Michael J, Gupta Richa, Gao Xiong-Zhuo, Cahill Karyn B, Chu Feixia, Cote Rick H

Abstract excerpt

Photoreceptor phosphodiesterase 6 (PDE6) is the central effector of the visual excitation pathway in both rod and cone photoreceptors, and PDE6 mutations that alter PDE6 structure or regulation can result in several human retinal diseases. The rod PDE6 holoenzyme consists of two catalytic subunits (Pαβ) whose activity is suppressed in the dark by binding of two inhibitory γ-subunits (Pγ). Upon photoactivation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross-Linking Reagents
Share to Cryoelectron Microscopy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclic Nucleotide Phosphodiesterases, Type 6

Share to GTP-Binding Proteins

Share to Holoenzymes

Share to Rhodopsin

Share to Transducin

Share to Vision, Ocular

Source

Open in PubMed Open full text

Identifiers

PMID: 31690623
DOI: 10.1074/jbc.RA119.011002
PMCID: PMC6926442

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The molecular architecture of photoreceptor phosphodiesterase 6 (PDE6) with activated G protein elucidates the mechanism of visual excitation.PMID 31690623Read ↗

Network and atomistic simulations unveil the structural determinants of mutations linked to retinal diseases.Semantic proximity Read ↗

Precision vs flexibility in GPCR signaling.Semantic proximity Read ↗

Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin.Semantic proximity Read ↗

Functional asymmetry and essential structural roles of PDE6α and PDE6β subunits in rod-photoreceptor integrity.Semantic proximity Read ↗

Regulation of photoreceptor phosphodiesterase (PDE6) by phosphorylation of its inhibitory gamma subunit re-evaluated.Semantic proximity Read ↗

Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants.Semantic proximity Read ↗

First 3D-Structural Data of Full-length Rod-Outer-Segment Guanylyl Cyclase 1 in Bovine Retina by Cross-linking/Mass SpectrometrySemantic proximity Read ↗

CryoEM structure of mGlu6 captures receptor activation prior to G protein coupling.Semantic proximity Read ↗

The Molecular Organization of Human cGMP Specific Phosphodiesterase 6 (PDE6): Structural Implications of Somatic Mutations in Cancer and Retinitis PigmentosaSemantic proximity Read ↗

The GAFa domain of phosphodiesterase-6 contains a rod outer segment localization signal.Semantic proximity Read ↗

Structural and functional investigation of RD3-GCAP1 interaction in retinal photoreceptors under normal and disease conditions.Semantic proximity Read ↗

Mutation R238E in transducin-alpha yields a GTPase and effector-deficient, but not dominant-negative, G-protein alpha-subunit.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.